After 4 days of treatment with 10 μM ATRA, SLC1A1 mRNA was increased by 400% compared with the control, and the C6 culture was greatly enriched of cells with bipolar morphology strongly positive for SLC1A1 immunoreactivity. Thus, the increased expression of SLC1A1 was correlated with the differentiation of glioma (12). This evidence concerns the gene SLC1A1 and central nervous system cancer.