Furthermore, the sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) was shown to hydrolyze the active metabolite of cytarabine, cytarabine triphosphate (ara-CTP), and also be involved in cytarabine resistance of AML cells [12,13]. The gene discussed is SAMHD1; the disease is acute myeloid leukemia.