CRC has been recently classified, based on molecular and microenvironmental characteristics of the primary tumour, into four molecular subtypes (CMSs): CMS1 (microsatellite instability immune) with hyper- mutations, MSI and strong immune activation; CMS2 (canonical) including an epithelial phenotype with WNT and MYC signalling activation; CMS3 (metabolic) exhibiting epithelial phenotype and metabolic dysregulation; and CMS4 (mesenchymal) characterized by TGFB signalling activation, stromal invasion and angiogenesis [6]. Here, TGFB1 is linked to colorectal carcinoma.