RPS14 and Diamond-Blackfan anemia: For example, the Diamond-Blackfan Anemia (DBA) is caused by heterozygous loss-of-function mutations in genes encoding RPs, such as RPS19, RPL5, and RPL11, while the 5q-syndrome is caused by a somatically acquired deletion of chromosome 5q, which leads to haploinsufficiency of RPS14.