TP53 and cancer: Secondly, the extra-ribosomal function of some RPs involved in ribosomopathies might also be relevant to promoting the oncogenic action of ribosome defects, as some of these functions relate to regulation of major cancer genes such as TP53 and MYC. The third category highlights the influence of ribosome defects on various cellular stress conditions, which can favor a specific translational program as well as promote the acquisition of potentially rescuing mutations.