Models of DBA also present enhanced oxidative stress and DNA damage: RPL5 (uL18) and RPS19 (eS19)-deficient mouse erythroleukemia-DBA clones and DBA patient samples display increased ROS levels, with higher levels of γH2A.X stained double strand DNA breaks and 8-oxoguanine oxidative DNA damage [70]. This evidence concerns the gene RPS19 and Diamond-Blackfan anemia.