RPS19 and Diamond-Blackfan anemia: Upregulation of ROS scavengers is however not a generalized phenotype in ribosomopathies: expression of genes involved in ROS detoxification, such as superoxide dismutase 2, is decreased in DBA models such as Rpl11 (uL5) zebrafish mutants and RPS19 (eS19)-deficient human cell lines [74,75].