CASP8 and Alzheimer disease: This study includes several important genes involved in APP processing, such as Adam10, App, Lpl, ApoE, Appbp1, Snca, Casp8, Psen1, Pen-2, Ide, Nep, Base1, Ncstn, and Aph1b. PCR-based expression analysis showed that App, Snca, Appbp, Lpl, and Casp8 were significantly overexpressed in AD transgenic mouse models as compared to wild-type mice (Figure 1).