SERPINE1 and preeclampsia: Women with preeclampsia show activity of an auto-antibody against the AT1 receptor, effecting the function of placenta, kidneys and other organs via (a) increased hypoxia induced SFlt-1 release interfering with angiogenesis, (b) increased placental and renal release of plasminogen activator inhibitor-1 (PAI-1) with reduced trophoblast invasion, reduced turn-over of extracellular matrix and increased renal sub-endothelial fibrin deposits, (c) stimulation of ROS production, (d) increase of intracellular calcium concentrations and (e) increase of coagulation by tissue factor (TF) [4,27].