These findings support the hypothesis that people with prediabetes/insulin resistance should to a larger extent rely on satiety hormones that are released mainly in response to fats and protein [for example, cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY)] reaching the small intestine dietary fat [27] and/or dietary fiber, for glycaemia control [28] and to enable weight loss and combat weight regain [13]. This evidence concerns the gene CCK and prediabetes syndrome.