This study identified modest differences in diet-specific weight loss between glycemic phenotypes, indicating that subjects with normoglycemia could benefit the most from low-fat/high-protein diets, subjects with prediabetes (and low insulin) could benefit the most from diets high in dietary fiber, and subjects with insulin resistance (high HOMA-IR) could benefit the most from high-fat/high-protein diets. This evidence concerns the gene INS and prediabetes syndrome.