IL-1β has been detected in synovial fluid of OA patients at concentrations of 1.25–100 pg/mL [13,14], representing a low level of inflammation compared to other chronic degenerative and inflammatory joint diseases like rheumatoid arthritis, in which IL-1β levels can reach up to 15 pg/mL, accompanied by very high TNF-α concentrations [15]. This evidence concerns the gene IL1B and rheumatoid arthritis.