One experiment demonstrated that cZNF292 reticent inhibits spheroid germination and endothelial cell tube formation.28 CircRNA_000203 sponge of miR‐26b‐5p, Col1a2, Col3a1, and α‐SMA increases expression and then stimulates pro‐fibrosis circRNA in mouse cardiac fibroblasts.29 Moreover, profiling and bioinformatics analyses indicated that circRNA is a risk factor for hypertension.30 The gene discussed is COL3A1; the disease is hypertensive disorder.