DNM1L and type 2 diabetes mellitus: SNPs within DRP-1 were found to have an association with mtDNACN (result did not reach significance after Bonferroni correction) (Table 2), which may further support the potential role of fission proteins in regulating mtDNACN. Interestingly, DRP-1 has been implicated in T2D, whereby imbalances in DRP-1 signaling have been observed in diabetic mice [51].