For example, in the Effects of adding budesonide or colestipol to loperamide prophylaxis on neratinib-associated diarrhea in patients with HER2+ early-stage breast cancer (CONTROL) study,27 the lowest incidence of grade 3 diarrhea (10.8%) occurred in patients receiving loperamide in combination with colestipol. Here, ERBB2 is linked to breast cancer.