TIMP1 and Sorsby fundus dystrophy: Furthermore, mRNA levels of the fibrosis markers tissue inhibitor of matrix metalloproteinases-1 (Timp-1) and collagen type 1 α 1 (Col1α1) were significantly higher in the WD group compared to the SFD group in young mice (p = 0.036 for both markers) but not in advanced-age mice (p = 0.068 and p = 0.222, respectively) (Figure 1(g, h)).