SMARCA1 and cancer: Furthermore, SMARCB1 is a core member of the SWI/SNF complex where alterations of one or more members have been identified in up to 20% of all cancers (Helming et al., 2014; Kadoch et al., 2013) including malignant rhabdoid tumors (MRTs) and atypical teratoid rhabdoid tumors (ATRTs).