We performed RNA-sequencing and transcriptomic profiling to compare the RMC models to other renal tumors or tumors that harbor loss of SMARCB1. Specifically, we compared the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) RNA-sequencing data from pediatric renal tumors (e.g. Wilms Tumor, Clear Cell Sarcoma of the Kidney, and Malignant Rhabdoid Tumor) or normal kidney tissues with the RMC models using t-distributed stochastic neighbor embedding (tSNE) (Materials and methods). The gene discussed is SMARCB1; the disease is clear cell sarcoma of kidney.