While 68Ga-THPMe-PSMA was comparable to its HBED counterpart in PET imaging of tumours,28 other derivatives such as the 68Ga-THPMe-TATE and 68Ga-THPMe-RGD3 demonstrated a lower tumour/non-target organ ratio compared to 68Ga radiotracers based on DOTA chelators,27,31 revealing how different targets may benefit from chelators with different chemical properties and, in turn, the potential value of structural variants on this promising platform. This evidence concerns the gene FOLH1 and neoplasm.