IGHE and allergic disease: In contrast, it has been reported that low‐affinity IgE can compete with high‐affinity IgE for binding to Fcε receptors, resulting in the prevention of allergic reaction.36 The present data also suggest that well‐developed immunoglobulin isotype formation through oral food allergen sensitization found in the casein‐specific immunoglobulin isotype formation and in the black circles infants in group B with higher levels of OVA‐specific IgG1 associated with detectable IgG2 and low‐affinity IgE production, probably plays an important role in the development of oral tolerance.