UBE2L3 and Alzheimer disease: The genetic relationship between the 22q11.21 region and multiple autoimmune diseases has been extensively elucidated.46, 47, 48 Besides, SNPs near YDJC are suggested to be a pleiotropic locus between AD and Crohn disease.49 Lately, UBE2L3 has been identified as a hub gene in the gene regulatory networks of AD.50