ZYX and Alzheimer disease: Recently, zyxin has been identified as a novel target of Aβ metabolism in AD.26 Besides, Zyxin is a novel interacting partner of SIRT127 that is protective against aging‐associated pathologies like AD28 and IS.29 Here, ZYX was jointly associated with AD and IS (Pcombined = 2.63E−07) with P < 0.001 in each disease.