Poly(A) binding protein cytoplasmic 1 (PABPC1), one type of RNA‐binding proteins, is a central component of cytoplasmic stress granules comprising proteins and mRNAs stalled at the translation initiation step.62 Pathological stress granules play crucial roles in neurodegenerative disorders,63, 64 also in brain ischemia.65 Moreover, abnormal cytoplasmic inclusions of PABPC1 have been observed in human ALS spinal cord neurons.66, 67 In the present work, PABPC1 was differentially expressed in both the PFC (P = 1.90E−11) and hippocampal regions (P = 2.99E−04) of AD. The gene discussed is PABPC1; the disease is brain ischemia.