Based on the concise discussion about their biological significance, partial pleotropic genes underlying AD and IS were prioritized, includingZYX, EPHA1, MS4A4A, UBE2L3, PABPC1, HECTD4, PINX1, and TREM2. Consistent with our previous findings from the pathway‐oriented perspective,101 we once again highlighted the critical roles of neuroinflammation in the development and progression of AD and IS, since half of them (EPHA1, MS4A4A, UBE2L3 and TREM2) were engaged in immune signaling. Here, HECTD4 is linked to Alzheimer disease.