AD‐associated expression profiles from the PFC region (Supporting Information Table S3A) revealed that 8 genes were differentially expressed, with MS4A4A, UBE2L3,TREM2, and HECTD4 being the most significant, while just 3 genes’ expression levels (HECTD4, YDJC, and PABPC1) were altered in the hippocampal regions compared with control brains (Supporting Information Table S3B). This evidence concerns the gene HECTD4 and Alzheimer disease.