Mounting GWAS studies have demonstrated the pleiotropic effects of 12q24 locus on type 1 diabetes,68, 69 celiac disease,70 coronary artery disease 71, 72, 73 and a number of cardiovascular risk factors, including hypertension,72, 74, 75 cholesterol levels,72, 76 whist‐hip ration,77 and glycemia.78 Importantly, the 12q24 region has been suggested to be a risk locus of IS.79 Recently, SNPs near HECTD4 are shown to be associated with memory performance.80 HECT domain E3 ubiquitin‐protein ligase 4 (HECTD4) is a E3 ubiquitin‐protein ligase. This evidence concerns the gene HECTD4 and type 1 diabetes mellitus.