PLK1 and cancer: Contrary, other research groups published that Plk1 inhibition using small interfering RNA (siRNA) or GSK461364 preferentially reduced the survival of p53−/− cancer cells by inducing mitotic arrest, chromosome instability, and cell death, while p53 wild‐type cells activated a postmitotic checkpoint, leading to a pseudo G1 phase arrest and survival (Brassesco et al., 2013; Danovi et al., 2013; Degenhardt et al., 2010; McInnes and Wyatt, 2011; Yim and Erikson, 2014).