Further research has been undertaken to identify cartilage damage, to establish diagnostic tools for other OADs, specially rheumatoid arthritis, to measure pro- and anti-inflammatory cytokines such as IL-10, TNF-α, collagen 4-hydroxyproline (O-Hyp) and hyaluronic acid (synovits) both in volume and chemical compositions which are not at all possible with the help of either x-ray or MRI imaging. This evidence concerns the gene TNF and rheumatoid arthritis.