However, a number of melanoma patients do have tumors that present both truncating mutations in NF1 as well as oncogenic mutations in BRAF. Interestingly, all of the BRAF mutations that show co-occurrence with NF1 truncating mutations, both lung adenocarcinoma and melanoma samples, do not present the V600E hotspot mutation. This evidence concerns the gene NF1 and lung adenocarcinoma.