PTCH1 and nevoid basal cell carcinoma syndrome: To study whether rapamycin treatment affected cells derived from BCNS patients with PTCH1 mutation differently than normal samples, we generated a gene list of the top differentially regulated and statistically significant genes (cut-off p-value with FDR <0.05, FC>1.3 or <-1.3), including the top genes as listed in Tables 3 and 4 (the entire gene list is available in Supplementary File 4).