Similar analysis of fibroblast samples that was based on 3496 differentially expressed genes common to both normal and BCNS fibroblasts resulted in enrichment of canonical pathways involving cell cycle control of chromosomal replication, role of BRCA1 in DNA damage response, mitotic roles of Polo-like kinase, hereditary breast cancer signaling and role of CHK proteins in Cell cycle checkpoint control. This evidence concerns the gene BRCA1 and Hereditary breast cancer.