Also, oncogenic signatures comprising of YAP [50, 51] conserved signature, up-regulated genes in RB1 and RBL2 skin specific knockout primary keratinocytes, genes upregulated upon EED or EZH2 knockdown, MYC overexpression, stimulation with Shh, and genes upregulated by everolimus, were found to be negatively correlated with treated BCNS fibroblasts. Here, RB1 is linked to nevoid basal cell carcinoma syndrome.