Additionally, genes expressed in multipotent progenitors, genes upregulated by APC or BCL3 knockout or RNAi mediated ELK3 knockdown in response to hypoxia, MYC and IRF4 targets, along with genes downregulated in lesional skin biopsies from mycosis fungoides patients compared to normal skin samples and genes upregulated in peripheral blood monocytes of Sezary syndrome, were negatively correlated with rapamycin-treated BCNS fibroblasts. This evidence concerns the gene IRF4 and Sezary syndrome.