The oncogenic signatures comprising of down-regulated genes leading to CTNNB1 overexpression, SRC overexpression, oncogenic KRAS expression in context of TBK1 knockdown, RNAi mediated knockdown of genes such as EIF4G1, HOXA9 and RPS14, and genes down-regulated after VEGFA treatment, positively correlated with BCNS keratinocytes after rapamycin treatment (data not shown). This evidence concerns the gene HOXA9 and nevoid basal cell carcinoma syndrome.