On the other hand, a core analysis of 4959 genes enriched in rapamycin treated BCNS fibroblasts pointed to top canonical pathways that included those playing a role of BRCA1 in DNA damage response, protein ubiquitination pathway, hereditary breast cancer signaling, cell cycle control of chromosomal replication and mitotic roles of Polo-like Kinases (Figure 5D, Table 5D). The gene discussed is BRCA1; the disease is Hereditary breast cancer.