The top up-regulated genes at baseline in BCNS fibroblasts were TMEM155, ABAT, BEX1, PDE4DIP, CPM, HNMT, SFRP2, AKR1C3, RAB27B, PLAC8, whereas GOLGA8A/GOLGA8B, NEAT1, MALAT1, MEG3, COL4A1, BCAT1, E2F7, FN1, LOC100190986, HELLS were the most down-regulated (Table 2). Here, AKR1C3 is linked to nevoid basal cell carcinoma syndrome.