CTNNB1 and nevoid basal cell carcinoma syndrome: In the case of BCNS fibroblasts, compared with normal fibroblasts, GSEA pointed to a negative correlation with three oncogenic signatures in the MsigDb that comprised genes down-regulated in response to activated CTNNB1 overexpression (BCAT_BILD_ET_AL_DN) and RNAi-mediated JAK2 knockdown (JAK2_DN.V1_DN), and genes up-regulated upon RNAi-mediated knockdown of PCGF2 (MEL18_DN.V1_UP) (Figure 2B).