Oncogenic signatures comprising of up-regulated genes in primary keratinocytes from RB1 and RBL2 skin specific knockout, genes upregulated upon EED or EZH2 knockdown, MYC overexpression, stimulation with Shh, and genes upregulated by everolimus are found to be correlated with treated BCNS fibroblasts. This evidence concerns the gene RBL2 and nevoid basal cell carcinoma syndrome.