The top up-regulated genes at baseline in keratinocytes derived from BCNS patients were NFIA-AS2, RBMY3AP, SEC16B, CROCC, SYN1, MKL1, FAM71A, LOC101928973, SIM2, GNG8 in comparison to normal keratinocytes, whereas GSTT1, STEAP4, NHLH2, MAST4, KLHL24, MALAT1, ARRDC3, LOC101928100, PELI, SLC28A3 were the most down-regulated genes (Table 2). The gene discussed is SIM2; the disease is nevoid basal cell carcinoma syndrome.