PIK3CA and nevoid basal cell carcinoma syndrome: Furthermore, GSEA indicated genes involved in glycogenesis and gluconeogenesis and genes upregulated by PI3K/AKT/mTOR pathway and mTORC1 complex activation, genes important for and involved in mitotic spindle assembly, DNA repair, G2/M checkpoint, genes responding to estrogen and genes regulated by MYC [49] were negatively correlated with the transcriptomic profiles of BCNS fibroblasts post rapamycin treatment.