To verify the role of NF-κB and ER stress in the proliferation and hypertrophy of VSMCs in hyperglycemia condition, we treated A7r5 cells in 33 mmol/L glucose with or without the ACHP (pharmacological inhibitor of IKK) and taurine (pharmacological inhibitor of IRE-1). This evidence concerns the gene NFKB1 and Hyperglycemia.