Furthermore, the results of immunohistochemical staining manifested that cells expressed Ki-67 and vimentin in tumor tissue of si-XIST group was obviously less than that of NC group, while E-cadherin was increased (Fig. 4d–g), indicating that the downregulation of XIST could inhibit cancer cell proliferation and EMT process in vivo. This evidence concerns the gene XIST and neoplasm.