ORC1 and cervical cancer: To further understand the role of ORC1 in cervical cancer, we designed siRNAs specifically targeting ORC1 (si-ORC1-1, si-ORC1-2), and the result of qRT-PCR showed si-ORC1-2 had the best effect for knockdown the expression ORC1, so it was used in the next experiments (Fig. 9a).