Importantly, analysis of available ChIP-seq data for BRG1 [43, 44], a catalytic subunit of SWI/SNF complex, in mouse macrophages and RN2 cells (murine MLL-AF9/NrasG12D AML cells) showed extensive overlap of its occupancy with open chromatin regions at Cebpa, Cd34, Csf1, IL6ra, and Gata2 loci (Fig. 6d and Supplementary Figure 10), thus substantiating SWI/SNF complex-mediated regulation of chromatin architecture at these loci. This evidence concerns the gene KMT2A and acute myeloid leukemia.