However, no signs of enhanced lymphoproliferative phenotype was reported in the IL-17RA deficient B6.lpr mice which may be due to the poly I:C induced TLR3 stimulation with enhanced type I interferon induction in this cGN lupus model before significant lymphoproliferation starts to develop spontaneously as we have shown in this study. Here, TLR3 is linked to childhood gender nonconformity.