However, BAFF can activate B cells and myeloid cells via the BAFF receptor to activate CISK (Act1), indicating that the CISK/Act1 KO may have a broader impact in different signaling pathways in the development of SLE than the IL-17RA KO/lpr in our study14. The gene discussed is TNFSF13B; the disease is systemic lupus erythematosus.