In this study, we show that atherosclerosis was suppressed in the ApoE-KO/PGC-1α mice, and the mRNA expression levels of FNDC5 and the genes involved in BAIBA biosynthesis in skeletal muscle were increased about 2-fold in the ApoE-KO/PGC-1α mice. This evidence concerns the gene PPARGC1A and atherosclerosis.