PPARGC1A and atherosclerosis: However, plasma TBARS levels and mRNA expression of eNOS in the aorta were not improved in 16 to 20-week-old ApoE-KO mice by overexpression of PGC-1α in skeletal muscles, suggesting that plasma lipid profiles and antioxidant systems were not involved in the suppression of atherosclerosis observed in ApoE-KO/PGC-1α mice.