TNF and herpes simplex infectious disease: Based on the Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway analysis, the six most enriched pathways were herpes simplex infection (mmu05168), influenza (mmu05164), tumour necrosis factor (TNF) signalling pathway (mmu04668), measles (mmu05162), leishmaniasis (mmu05140), and phagosome (mmu04145) (Fig. 1D).