The autosomal dominant polycystic kidney disease mutation database (PKDB) established by the Mayo Clinic lists 1243 definite pathogenic PKD1 variants out of the 2055 listed variants and 374 definite pathogenic PKD2 variants out of the 463 listed variants (http://pkdb.mayo.edu). The gene discussed is PKD2; the disease is autosomal dominant polycystic kidney disease.