No previous genome-wide significant associations of the locus with coronary artery disease have been identified; however, BCAR1-CFDP1-TMEM170A locus (just 80 kb from our novel SNP) has been found to be suggestively associated with and functionally implicated in carotid intima-media thickness26,27, and had genome-wide significant association with aortic root diameter (a marker of cardiac structure)28. Here, TMEM170A is linked to coronary artery disorder.