Specifically, birthweight exhibits significant inverse genetic correlations with type 2 diabetes, fasting insulin, glycated hemoglobin, waist-to-hip ratio, coronary artery disease, high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), total cholesterol, and total glycerides, and significant positive genetic correlations with BMI and waist circumference14,15. The gene discussed is INS; the disease is type 2 diabetes mellitus.