Several other genes seen to be hypermethylated are under protein kinase A signaling control, including PHKB, PHKG2, PTPN11 and CDC27. Among these, PTPN11 plays a role in lens and retinal development99,100 and found to be associated with myopia7, and two other hypermethylated genes in our study, FBN1 and OCA2, were also found to be associated with myopia in the same study7 and FBN1 is associated with refractive error101. This evidence concerns the gene PHKB and myopia.