In ccRCC specifically, the large TCGA cohort of 448 cases reports no point mutations and only one tumour with a deep deletion of KLF6. In this particular case, KLF6 is lost together with several other genes on chromosome 10p, suggesting that the alteration is not specifically targeting KLF6. On the other hand, the expression and chromatin alteration patterns we observe in human ccRCCs and cell lines are supportive of a pro-tumorigenic role for KLF6. This evidence concerns the gene KLF6 and nonpapillary renal cell carcinoma.