In vivo tumorigenesis experiments revealed significant decreases in tumor growth, tumor weight, and Ki67-positive staining upon silencing of GLS, GOT2, or ASNS in SW480-SOX12 cells (Fig. 5b), whereas GLS, GOT2, or ASNS overexpression reversed the SOX12 knockdown-induced suppression of tumor growth (Fig. 5c). Here, SOX12 is linked to neoplasm.