SOX12, a direct target of hypoxia-inducible factor 1α (HIF-1α), promotes CRC cell proliferation and metastasis by regulating three key enzymes, glutaminase (GLS), glutamic oxaloacetic transaminase 2 (GOT2), and asparagine synthetase (ASNS), in asparagine biosynthesis. Here, HIF1A is linked to colorectal carcinoma.