Patients coexpressing SOX12 and HIF-1α, SOX12 and GLS, SOX12 and GOT2, or SOX12 and ASNS showed the highest recurrence rates and the lowest OS rates according to Kaplan–Meier analysis (Fig. 8c–f), suggesting that the HIF-1α/SOX12/GLS/GOT2/ASNS pathway contributes to CRC progression and can predict poor prognosis. This evidence concerns the gene HIF1A and colorectal carcinoma.