Accordingly, we found that NAA40 reduction and subsequent downregulation of PRMT5 results in decreased expression of Fibroblast Growth Factor Receptor 3 (FGFR3) and Eukaryotic Translation Initiation Factor 4E (EIF4E) oncogenes and derepression of RB Transcriptional Corepressor Like 2 (RBL2) and Cyclin Dependent Kinase Inhibitor 1 A (CDKN1A) tumor suppressors, which, respectively, are activated and repressed by PRMT5 in proliferating CRC cells (Fig. 5e and Supplementary Figures S3D and S4D). This evidence concerns the gene CDKN1A and colorectal carcinoma.