However, mutation in H133 or E94 site did not affect ADI1 effects on apoptosis or cell proliferation in LNCaP cells (a prostate cancer cell line), which was quite different from our findings in HCC cell lines, as H133A mutation abolished both functions of ADI1 in cell growth inhibition and apoptosis enhancement (Fig. 3). Here, ADI1 is linked to Familial prostate cancer.