TP73 and cancer: By literature searching, we further discovered that some of them were implied as oncogenes in numerous types of cancers, such as TP73-AS1 in HCC19 (Supplementary Fig. S5), LINC00511 in non-small cell lung cancer20 (Supplementary Fig. S6) as well as miR-371 in HCC and pancreatic cancer21,22 (Supplementary Fig. S7), supporting our hypothesis that the expression of genes with hyper-methylated promoter might affect gene expression.