More specifically, our results provide evidence in humans that support the mice findings, that gene inactivation of IFNGR1, RABEPK, and MIF induces tumors resistant to PD1 blockade and gene inactivation of PDIA3, STUB1, CDC7, UBQLN1, NCSTN, GNG12, and GPI co‐simulates immune response to PD1 blockade in melanoma. Here, PDIA3 is linked to melanoma.