To test the predicted rescue interactions involving mTOR, we knocked down (KD) genes in an experimental screen in a head and neck cancer cell line (HN12) and experimentally identified the (DD) rescue events occurring due to a subsequent mTOR inhibition by rapamycin treatment (which is known to specifically targets mTOR in its complex 1; Laplante & Sabatini, 2012). Here, MTOR is linked to head and neck cancer.