Interestingly, whereas comparable levels of CD4+ and CD8+ T cells were observed in normal (NOR), adjacent (ADJ) or tumor tissue (CA), DNT cell frequency was significantly reduced in tumor tissues compared to adjacent or normal lung tissues (CA:4.2 ± 0.2% vs ADJ:6.5 ± 0.6% and NOR:7.0 ± 0.7%, respectively; Fig. 1b). Here, CD8A is linked to neoplasm.