As the changes of three epigenetic modifications simultaneously occur in the promoter region of TLR4 in CD14+ monocytes of CAD patients according to our results, all of three epigenetic modifiers DNMT1, HDAC1, and SUV39H1 were important for RFX1-mediated epigenetic regulation on TLR4 expression in CD14+ monocytes of CAD patients. The gene discussed is TLR4; the disease is coronary artery disorder.