RFX1 downregulation caused CD11a, CD70, and IL17A overexpression by reducing DNA methylation and increasing H3 acetylation levels in the promoter region of CD11a, CD70, and IL17A in the CD4+ T cells of systemic lupus erythematosus (SLE) patients, which contributed to autoimmune responses [31, 33]. The gene discussed is ITGAL; the disease is systemic lupus erythematosus.