ChIP-qPCR analysis indicated that the acetylation of H3 (Fig. 5e, f) and H4 (Fig. 5g, h) in RFX1 binding region of the TLR4 promoter were significantly increased, while the trimethylation of H3K9 (Fig. 5i, j) in RFX1 binding region of the TLR4 promoter was significantly decreased in the CD14+ monocytes from CAD patients and the LDL-treated CD14+ monocytes compared with the non-CAD controls or negative controls, respectively. This evidence concerns the gene RFX1 and coronary artery disorder.