First, we found that the enrichments of RFX1, DNMT1, HDAC1, and SUV39H1 in the TLR4 promoter region was decreased in the CD14+ monocytes from the CAD patients and in the LDL-treated CD14+ monocytes compared with the corresponding negative controls (Fig. 8a–h). This evidence concerns the gene RFX1 and coronary artery disorder.