TP53 and neoplasm: In addition, we overexpressed p53 after knocking down hsa_circ_0055538 and performed a CCK-8 assay, scratch assay, and invasion assay, which revealed that the proliferation (Fig. 5e, f), migration (Fig. 6a, b), and invasion (Fig. 6c) of the tumor cells in the experimental group were inhibited compared with those in the control group.