The Atherosclerosis Risk in Communities Study showed a significant interaction among the GNB3 C825T polymorphism, obesity status, and physical activity in predicting hypertension in African American subjects, and those who were both obese and had a low activity level with T allele were 2.7 times more likely to be hypertensive compared to non-obese, active C homozygotes [52]. The gene discussed is GNB3; the disease is hypertensive disorder.