NFE2L2 and Alzheimer disease: In relation to this, it has been observed that curcumin alleviates airway inflammation and ameliorates the expression of pro-inflammatory cytokines through the phosphorilation of nuclear factor-erythroid 2 related factor 2 together with the expression of heme oxygenase-1 (Nrf2/HO-1 signaling pathway) [16]; curcumin, being an amyloid-binding probe, reduces chronic inflammation, facilitates resolution of inflammation, and reduces lipid peroxidation that is correlated with synapse loss, causing it to have beneficial effects in Alzheimer’s disease [17].