ESR1 and carcinoma: There is strong evidence that ER and AR can be the MIE of the AOP framework, such as androgen receptor agonism leading to reproductive dysfunction (https://aopwiki.org/aops/23), androgen receptor activation leading to hepatocellular adenomas and carcinomas (https://aopwiki.org/aops/117) and estrogen receptor agonism leading to reproductive dysfunction (https://aopwiki.org/aops/30).