While the lack of significant difference in NK cell phenotype and function of NKG2Cnull compared to NKG2C-expressing individuals may be one more example of immune system redundancy, the ultimate significance of an expanded population of NKG2Cpos NK cells and role of NKG2C towards controlling HCMV infection or stimulating NK cell expansion and adaptation might be questioned. Here, KLRC2 is linked to cytomegalovirus infection.