It was followed by a clinical trial (NOA-16) of the IDH1 peptide vaccine targeting the IDH1-R132H to evaluate the safety and tolerability, as well as immune responses to the vaccine in patients having IDH1-R132H malignant gliomas (https://clinicaltrials.gov/ct2/show/NCT02454634). The gene discussed is IDH1; the disease is malignant glioma.