Many studies showed that patients with IDH-mut gliomas have better survival compared to their IDH-wt counterparts irrespective of histology and grade, making IDH mutation the most important prognostic factor for survival, followed by age, tumor grade, and O6-methylguanine-DNA methyltransferase gene (MGMT) status (reviewed in Reference [28]). The gene discussed is MGMT; the disease is glioma.