In IDH-mut gliomas (R)-2HG acts as an activator of EGLN prolyl 4-hydroxylases, leading to decreased levels of HIF1α and reduced expression of genes implicated in hypoxia, and vasculo- and angiogenesis-related signaling such as: VEGFA, PDGF (platelet derived growth factor), or ANGPT2 (angiopoietin-2) [65]. This evidence concerns the gene ANGPT2 and central nervous system cancer.