NTRK3, also known as TrkC, was found as a dependency receptor in colorectal cancer where its tumour suppressor or oncogenic function is dependent on the expression of its ligand NT-3; specifically, the receptor–ligand interaction promotes cell survival, but in the NT-3-free form, NTRK3 becomes a tumour suppressor by inducing apoptosis [30]. The gene discussed is NTRK3; the disease is colorectal cancer.