SLC5A2 and diabetes mellitus: Several other mechanisms, specifically affected by DM, seem to be significantly involved in increasing cardiomyocytes’ stiffness: (i) impairment of myocardial nitric oxide (NO) pathway, (ii) coronary microvascular dysfunction, (iii) increased inflammation and oxidative stress, and (iv) myocardium-sodium glucose cotransporter-2 (SGLT-2) related defects.