PECAM1 and Insulin resistance: The results herein are in line with previous in vitro work, as we report that platelet-derived (AV− CD31+/CD41+) EVs and the PECAM EV AV− CD31+ are significantly related to the postprandial insulin response during an OGTT, see Figure 3A, as well as higher total, leukocyte (AV+ CD45+), and endothelial EVs (AV+ CD105) correlate with adipose insulin resistance, which is consistent with work showing that insulin resistance increases EVs secretion and alters circulating leukocyte function [32].