HPGDS and cancer: The ability of Nrf2 to activate cyto-protective detoxifying enzymes systems, including the cytochrome P450 (CYP) system, glutathione-S-transferase (GST), and uridine diphospho-glucuronosyltransferase (UGT), plays a crucial role in reducing ROS, leading to the prevention of apoptosis in cancer cells [100,101].