Epidemiological studies have reported that levels of pro-inflammatory and inflammatory cytokines such as C-reactive protein (CRP), TNF-α, IL-1β, and IL-6 were elevated in patients with type 2 diabetes and were associated with the development of type 2 diabetes [3,17,18,19,20,21,22,23,24,25]. This evidence concerns the gene IL1B and type 2 diabetes mellitus.