We also found that VLDL-C levels were inversely correlated with adiponectin levels independently of age, body mass index (BMI), gender, and glycemic control in patients with type 2 diabetes [82] The reported association of circulating adiponectin with VLDL apoB100 fractional catabolic rate suggests that the regulation of serum VLDL-C by adiponectin may involve VLDL catabolism [79,83,84]. This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.