In the population-based Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA)/Cooperative Health Research in the Region of Augsburg (KORA) cohort study between 1984 and 1995 with follow-up until 2002 (mean follow-up 10.9 ± 4.7 years) [55], low levels of adiponectin were associated with an increased type 2 diabetes risk. This evidence concerns the gene ADIPOQ and cardiovascular disorder.