The results are also consistent with a recent study reporting that iron accumulation in hematopoietic stem cells from FBXL5 deficient mice, resulted in impaired hematopoiesis bud did not substantially affect more differentiated hematopoietic cells [22] and are also in agreement with a recent study reporting that iron overload, induced via iron dextran administration, impaired erythroid cells development in a mouse model of myelodysplastic syndrome [38]. Here, FBXL5 is linked to myelodysplastic syndrome.