INSR and neoplasm: Another example is the splicing factor SRSF6, which via a fine-tuning of its expression, is able to alter the splicing of several oncogenes, including the insulin receptor (INSR), the kinase Mnk2 (MKNK2) and the discs large MAGUK scaffold protein 1 (DLG1) leading to the production of oncogenic isoforms or to the reduction of the tumour-suppressing isoforms [10].